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Long-term drinking can affect multiple links of the gut-liver axis, such as damaging the intestinal mucosal barrier function, inducing intestinal flora imbalance, and abnormal bile acid metabolism ( Several clinical trials have shown that probiotics such as Lacticaseibacillus rhamnosus LGG improve acute or chronic alcoholic liver injury by regulating intestinal flora and repairing intestinal barrier function ( Rifaximin is a non-systemic antibiotic with broad-spectrum antibacterial activity and has high safety characteristics due to low intestinal absorption (Yang et al., 2024

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