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Ras leads to the activation of different mitogen-activated protein kinase (MAPK) cascades, including extracellular-signal-regulated kinase (ERK), p38 MAPK , and c-Jun N-terminal protein kinase (JNK) (Graziani et al., 1993)

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Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: Implications for substance use disorders