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An IgG antibody response to the 93 kDa Bb protein (also called P83/100), which includes a sequence that is a mimic of the fibronectin 2015–2029 peptide, is found in the majority of LA patients (21), and reactivity with this Bb protein was noted on Western blots of all 24 current study patients with postinfectious LA

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In zebrafish with congenital agaglionosis resulting from mutations in the sox10 gene, which lead to the absence of an ENS, microbiota-dependent inflammation occurs