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if the outer annulus fibrosus subsequently ruptures, the nucleus pulposus completely extrudes (non-contained herniation), potentially protruding into the spinal canal or lateral recess, compressing the cauda equina and nerve roots, causing pain or motor dysfunction (Figure 1)

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Stress induced through proteasomal inhibition, glucose starvation, glutamate toxicity, ER stress, or ROS generation activate NRF2 and ATF4 activity and upregulate xCT [36,37,39,50,51]