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Fenofibrate, a peroxisome-proliferator-activated receptor α agonist (PPARα agonist) originally prescribed for dyslipidemia, can efficiently reduce senescence burden in aged chondrocytes, improving osteoarthritis conditions in human patients, alleviating cartilage degradation, and mitigating inflammatory responses linked to osteoarthritis and reduced the Western Ontario and McMaster Universities Arthritis Index (WOMAC) osteoarthritis index