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In view of the ability of high doses of BHA to promote forestomach cancer in the rat, coupled with the fact that Nrf2 is a cell survival factor, it is reasonable to question whether activation of the transcription factor by chemopreventive agents once carcinogenesis has been initiated might serve to accelerate tumorigenesis rather than inhibit it

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Trollor JN, 2011, 'Neuroanatomical Correlates of Cognitive Performance in Late Life', Dementia and Geriatric Cognitive Disorders , 32, pp