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Meanwhile, two other clinical trials, one examining the effects of forskolin on IOP in glaucomatous patients (NCT00864578) and another evaluating its effects in patients undergoing treatment with beta-blockers or prostaglandin eye drops (NCT00863811), have been withdrawn

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NO reacts with O 2 − to produce peroxynitrite (ONOO − ), a molecule that can nitrate lipids, nucleic acids, aromatic rings, and the tyrosine residues in proteins leading to tyrosine nitration