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Using dCas9-Tet1 editing with a GG(CGG) 6 NGG single guide RNA, DNA demethylation was recently targeted to the CGG repeat with minimal off-target effects in induced pluripotent stem cells (iPSCs) derived from FXS patients [47]

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Flavonoids Studies have shown that formononetin can effectively reduce OCT2 expression and increase MRP expression, resulting in decreased accumulation of cisplatin in renal tubular cells [72]