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Interestingly, although we see that Cu 2+ alone revealed a pro-inflammatory effect by stimulating expression of TNF-α and IL-6, the combination of Cu 2+ with Zn 2+ and Qu completely suppressed the original pro-inflammatory effect of Cu 2+ and even displayed the best anti-inflammatory effect among all groups (Fig

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These findings provide support for the pivotal role of ferroptosis in epilepsy pathology (59)