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Amyloid overexpression stimulates mTORC1 signaling, inhibits mitophagy, and increases apoptosis
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(1997) demonstrated that perinatal exposure to 10 mg/ml Mn in drinking water induced hyperactivity in rats in association with cerebral cortex thickening, although no significant alterations in TH activity, dopamine, and GFAP levels were observed (Pappas et al., 1997), suggesting involvement of other potential mechanisms in addition to dopamine