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7 Briefly, Pubmed, Embase, Scopus, and Cochrane review search engines were queried with the following search terms: ‘child or adolescent’, ‘post-traumatic’, ‘headache’, ‘concussion’ OR ‘mild TBI’ and ‘treatment.’ Articles on moderate-to-severe TBI was excluded as it was out of the scope of this review

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As a NAD + hydrolase, CD38 significantly downregulates the level of NAD +