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SD-436 has no significant inhibition of the human ether-a-go-go-related gene potassium channels (hERG inhibition: 1.3% for 3μM and 1.1% for 30 μM) [1]

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Additionally, treatment of Caco-2 bearing mice with the NPs has downregulated anti-apoptotic factors including Survivin and Bcl-2, while upregulated pro-apoptotic Bax, Fas, caspase-3 and caspase-9 [14]