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It is worth noting that fludarabine as a single drug has no effect on the methylation of histone H3 in AML cells, but can promote the methylation of multiple sites of histone H3 when combined with clofarabine, which is a very interesting question and deserves further study (Valdez et al., 2011)

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doi:10.1016/j.atherosclerosis.2020.10.016 Onea HL, Spinu M, Homorodean C, et al