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Class I ferroptosis inducers (FINs), including sorafenib, sulfasalazine, erastin, and its analog imidazole ketone erastin, inhibit system Xc-, disturb the synthesis of GSH, and subsequently deplete GSH to suppress the GPX4 enzyme activity

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In a study by Urbonaviciene et al., serum IGF-1 and IGFBP-2 levels were measured in 440 patients with lower-extremity PAD, revealing an increased risk of CVD mortality was associated with an increase of 100 μg/l of baseline IGFBP-2 value