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Wnt3a −/− double knockout mice, absence of these Wnt members from the dorsal neural tube during later stages of otocyst development results in severe vestibular defects, including a complete lack of utricle and saccule

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One such gene is phosphatidylethanolamine N-methyltransferase ( PEMT ) (53), which encodes the enzyme that catalyzes the conversion of phosphatidylethanolamine to PC, through a three-step methylation process using S-adenosylmethionine (SAM) as methyl donor