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And it was found for the first time that ISL could inhibit Annexin A2 expression both in vivo and in vitro , block the sphingosine kinases/sphingosine-1-phosphate/IL-17 signaling pathway and regulate the expression of α-SMA by inhibiting the phosphorylation of STAT3 at the downstream signal to finally reverse HSCs activation and hepatic fibrosis (Liu et al., 2023)

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229 Due to the considerable genetic and clinical heterogeneity, mitochondrial diseases can affect either single or multiple organ systems, leading to a wide range of clinical manifestations (Fig