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Schematic pathways showing how glutathione can account for covariations... | Download Scientific Diagram

12 Based on the summary and analysis of existing research reports, this text concludes that whitening ingredients of natural products inhibit melanin deposition through five specific mechanisms: 1) Down-regulation of MITF expression: Interference with various molecular signaling pathways downregulates the protein expression of MITF, which subsequently affects the regulation of melanogenesis

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Procedures like fundoplications are commonly performed this way