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The study design should be appropriate in terms of (1) the pattern of consumption and quantity of the food/constituent in question, (2) the study group, which should be representative to extrapolate the findings to the general population, and (3) the outcome measures, which should be in accordance with rigorous methodological procedures included in generally accepted guidelines published by renowned institutions and societies in that area

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Cortisol, on the other hand, is a hormone produced by the adrenal glands in response to stress