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Specifically, all three classes of antibiotics induced a significant downregulation of crucial energy metabolites such as AMP, ADP, and NADP, which can impede bacterial energy production capacity and hinder essential biosynthetic pathways ( An intriguing aspect of the ROS response was observed, particularly in relation to downregulated antioxidant metabolites, such as glutathione, across all treatments

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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer