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A study using inulin-type fructans to treat NAFLD patients for 12 weeks found that, although it increased fecal Bifidobacterium content, it failed to significantly reduce liver fat content or improve metabolic and inflammatory mediators, indicating that without weight loss, prebiotic intervention alone may be insufficient to improve NAFLD

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Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future