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Transcription factors such as cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) (Zou et al., 2013), SP1 (Sun et al., 2015), p53 (Wang et al., 2016), hypoxia-inducible factor-1α (HIF-1α) (Geng et al., 2018), hormones (Sun et al., 2015) and MicroRNA (Chen et al., 2015

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Intra-islet somatostatin regulates glucagon release via type 2 somatostatin receptors in rats