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Whether the impact of anesthesia followed by pain management has the same effects on the antioxidant system as abuse of opioids, amphetamines and other drugs affecting these systems is an issue that needs further research since such effects may be assumed to be a function of drug dosage, means of delivery, length of use and the degree to which tolerance develops

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Additionally, the chelating ability of certain polyphenols for metal ions like iron and copper further augments their antioxidant potential (Rice‐Evans et al