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Examples of reversible covalent drugs on the market | Download Scientific Diagram

dPCD is involved in various plant developmental processes such as xylogenesis, trichome differentiation and leaf senescence, while ePCD is a vital counterbalance during plant response to abiotic and biotic stress

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While most of these are still in the preclinical ‘tool compound’ stage or have been limited by toxicity, allosteric inhibitors of GLS have shown promise in preclinical models of cancer, and one highly potent compound in this class, CB-839, has moved on to clinical trials