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The RMSD for Arbutin_c increased at the beginning of the simulation but eventually stabilized above 1.4 Å, while Arbutin_d maintained better stability, remaining below 1.4 Å throughout the simulation

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The substrate of sEH, 14,15-epoxyeicosatrienoic acid (14,15-EET), protected TH-positive cells and alleviated the rotarod performance deficits of wild-type mice, but not sEH-knockout mice